Disease-modifying therapies (DMTs)
Disease-modifying therapies — or DMTs — are the cornerstone of MS treatment. One of the most important things to understand at diagnosis is that starting a DMT early matters. The sooner treatment begins, the better the chance of slowing damage before it accumulates — and evidence consistently shows that early treatment leads to better long-term outcomes. If you've recently been diagnosed, this is one of the most valuable conversations you can have with your neurologist.
DMTs aren't a cure, but they can make a real difference to how MS develops over time. They reduce how many relapses you get, make relapses less serious when they do occur, and slow the damage that builds up over time. They work by dampening the immune system to reduce the inflammation that drives MS — though they can't repair damage that has already happened.
DMTs come in three forms: tablets, injections, and infusions. There are now more than 20 approved options — your neurologist can match the right one to your lifestyle, your MS, and your preferences.
Oral (tablet) therapies
Common side effect is flushing, usually settles within a few weeks.
Better GI tolerability than Tecfidera.
Requires regular liver monitoring.
First dose given under observation due to heart rate monitoring.
Also approved for active secondary progressive MS.
Gradual dose escalation at the start.
Gradual dose escalation at the start.
One of the few DMTs with a defined treatment course rather than ongoing daily medication.
Injectable therapies
Injected into the muscle; flu-like side effects common early on.
Injected under the skin; injection site reactions possible.
One of the longest-established MS treatments.
Less frequent dosing than other interferons.
Non-interferon option; well-established safety profile.
High efficacy delivered via a pen device at home.
Infusion therapies (given in clinic)
Very effective but requires JC virus monitoring due to PML risk.
Also the only DMT approved for primary progressive MS (PPMS).
Shorter infusion time than Ocrevus.
Powerful immune reset; requires intensive monitoring for several years after treatment.
Higher efficacy means stronger suppression of disease activity — but also closer monitoring and a more involved safety profile. The right choice depends on how active your MS is, your lifestyle, and what matters most to you. And it isn't fixed — if a treatment isn't working well enough or side effects become difficult, it can be changed.
It's also worth knowing that stem cell transplantation (AHSCT) is now considered a DMT — available as a later-line option for people with highly active RRMS who haven't responded to other treatments. Access varies, and it is currently only offered in some countries through specialist centres. Your neurologist is the best person to discuss whether this might be relevant for you.